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According to the FDAs brief , the concern was whether the stability of the peptide would hold during manufacturing and how much the quality of the compounded product could change as a result

J Toxicol Clin Toxicol 2000, 38: 219

Biochemical findings Serum and tissue levels of L-Arginine, ADMA SDMA, and NO were measured by taking blood samples from all subjects in the groups before sacrification, and also samples taken from the parenchyma after sacrification

And in a 2018 study, more people reported injection-site pain with Emgality pens than with the syringes